微小RNA调控的自噬在结直肠癌进展和耐药中的作用
Autophagy regulated by miRNAs in colorectal cancer progression and resistance.
作者信息
Fesler Andrew, Liu Hua, Wu Ning, Liu Fei, Ling Peixue, Ju Jingfang
机构信息
Department of Pathology, Stony Brook University, Stony Brook, NY 11794 USA.
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China.
出版信息
Cancer Transl Med. 2017;3(3):96-100. doi: 10.4103/ctm.ctm_64_16. Epub 2017 Jun 8.
Abstract
The catabolic process of autophagy is an essential cellular function that allows for the breakdown and recycling of cellular macromolecules. In recent years, the impact of epigenetic regulation of autophagy by non-coding microRNAs (miRNAs) has been recognized in human cancer. In colorectal cancer, Autophagy plays critical roles in cancer progression as well as resistance to chemotherapy, and recent evidence demonstrates that miRNAs are directly involved in mediating these functions. In this review, we will focus on the recent advancements in the field of miRNA regulation of autophagy in colorectal cancer.
摘要
自噬的分解代谢过程是一种重要的细胞功能，它允许细胞大分子进行分解和再循环。近年来，非编码微小RNA（miRNA）对自噬的表观遗传调控在人类癌症中的影响已得到认可。在结直肠癌中，自噬在癌症进展以及化疗耐药性中发挥着关键作用，最近的证据表明，miRNA直接参与介导这些功能。在本综述中，我们将聚焦于结直肠癌中miRNA调控自噬领域的最新进展。
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本文引用的文献
1
Autophagy-from molecular mechanisms to clinical relevance.
Cell Biol Toxicol. 2017 Apr;33(2):145-168. doi: 10.1007/s10565-016-9374-5. Epub 2016 Dec 12.
2
Autophagy in cancer metastasis.
Oncogene. 2017 Mar 23;36(12):1619-1630. doi: 10.1038/onc.2016.333. Epub 2016 Sep 5.
3
Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3.
Cell Rep. 2016 May 24;15(8):1660-72. doi: 10.1016/j.celrep.2016.04.065. Epub 2016 May 12.
4
miR-409-3p sensitizes colon cancer cells to oxaliplatin by inhibiting Beclin-1-mediated autophagy.
Int J Mol Med. 2016 Apr;37(4):1030-8. doi: 10.3892/ijmm.2016.2492. Epub 2016 Feb 18.
5
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Autophagy. 2016;12(1):1-222. doi: 10.1080/15548627.2015.1100356.
6
miR-183 regulates autophagy and apoptosis in colorectal cancer through targeting of UVRAG.
Oncotarget. 2016 Jan 26;7(4):4735-45. doi: 10.18632/oncotarget.6732.
7
Inhibition of colorectal cancer stem cell survival and invasive potential by hsa-miR-140-5p mediated suppression of Smad2 and autophagy.
Oncotarget. 2015 Aug 14;6(23):19735-46. doi: 10.18632/oncotarget.3771.
8
MicroRNA-124 inhibits cancer cell growth through PTB1/PKM1/PKM2 feedback cascade in colorectal cancer.
Cancer Lett. 2015 Jul 10;363(1):17-27. doi: 10.1016/j.canlet.2015.03.026. Epub 2015 Mar 24.
9
MiR-22 regulates 5-FU sensitivity by inhibiting autophagy and promoting apoptosis in colorectal cancer cells.
Cancer Lett. 2015 Jan 28;356(2 Pt B):781-90. doi: 10.1016/j.canlet.2014.10.029. Epub 2014 Oct 29.
10
Hypoxia-induced autophagy reduces radiosensitivity by the HIF-1α/miR-210/Bcl-2 pathway in colon cancer cells.
Int J Oncol. 2015 Feb;46(2):750-6. doi: 10.3892/ijo.2014.2745. Epub 2014 Nov 10.
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