微小RNA调控的自噬在结直肠癌进展和耐药中的作用
Autophagy regulated by miRNAs in colorectal cancer progression and resistance.
作者信息
Fesler Andrew, Liu Hua, Wu Ning, Liu Fei, Ling Peixue, Ju Jingfang
机构信息
Department of Pathology, Stony Brook University, Stony Brook, NY 11794 USA.
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China.
出版信息
Cancer Transl Med. 2017;3(3):96-100. doi: 10.4103/ctm.ctm_64_16. Epub 2017 Jun 8.
Abstract
The catabolic process of autophagy is an essential cellular function that allows for the breakdown and recycling of cellular macromolecules. In recent years, the impact of epigenetic regulation of autophagy by non-coding microRNAs (miRNAs) has been recognized in human cancer. In colorectal cancer, Autophagy plays critical roles in cancer progression as well as resistance to chemotherapy, and recent evidence demonstrates that miRNAs are directly involved in mediating these functions. In this review, we will focus on the recent advancements in the field of miRNA regulation of autophagy in colorectal cancer.
摘要
自噬的分解代谢过程是一种重要的细胞功能，它允许细胞大分子进行分解和再循环。近年来，非编码微小RNA（miRNA）对自噬的表观遗传调控在人类癌症中的影响已得到认可。在结直肠癌中，自噬在癌症进展以及化疗耐药性中发挥着关键作用，最近的证据表明，miRNA直接参与介导这些功能。在本综述中，我们将聚焦于结直肠癌中miRNA调控自噬领域的最新进展。
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