Department of Medicine, Hawassa University, Awassa, Ethiopia.
J Trop Pediatr. 2011 Feb;57(1):14-23. doi: 10.1093/tropej/fmq032. Epub 2010 May 19.
A review of the literature has revealed that data on HIV-infected clinical presentations, age at the time of diagnosis and level of immunosuppression in resource-poor settings are very limited. A multicenter retrospective and cross-sectional method was used to analyze 1163 children <15 years of age. More than half of the children were >5 years of age (mean ± SD age 4.9 ± 3.2). About 54% of children were symptomatic. Tuberculosis and chronic dermatologic disorders were the commonest co-infections. The severity of immunosuppression was highest in preschool children (46.6%) and early adolescents (41.3%). After adjustment for sex, age, pattern of feeding and hemoglobin level, multinomial logistic regression showed that CD4 count 200-499, 500-999 and Tigray ethnicity were independently associated with being symptomatic. More than one-third of the children were in a state of severe immunosuppression and more than half were immunologically eligible for antiretroviral treatment.
文献回顾表明，资源匮乏环境下关于 HIV 感染者临床表现、诊断时年龄和免疫抑制程度的数据非常有限。采用多中心回顾性和横断面方法分析了 1163 名 <15 岁的儿童。超过一半的儿童年龄>5 岁（平均±标准差年龄 4.9±3.2）。约 54%的儿童有症状。结核病和慢性皮肤病是最常见的合并感染。在学龄前儿童（46.6%）和青春期早期（41.3%），免疫抑制程度最高。在调整性别、年龄、喂养模式和血红蛋白水平后，多分类逻辑回归显示 CD4 计数 200-499、500-999 和提格雷种族与有症状独立相关。超过三分之一的儿童处于严重免疫抑制状态，超过一半的儿童在免疫学上有资格接受抗逆转录病毒治疗。
