Dolan S M, Hollegaard M V, Merialdi M, Betran A P, Allen T, Abelow C, Nace J, Lin B K, Khoury M J, Ioannidis J P A, Bagade S, Zheng X, Dubin R A, Bertram L, Velez Edwards D R, Menon R
Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY 10461, USA.
Public Health Genomics. 2010;13(7-8):514-23. doi: 10.1159/000294202. Epub 2010 May 20.
Our goal wasto produce a field synopsis of genetic associations with preterm birth and to set up a publicly available online database summarizing the data.
We performed a systematic review and meta-analyses to identify genetic associations with preterm birth. We have set up a publicly available online database of genetic association data on preterm birth called PTBGene (http://ric.einstein.yu.edu/ptbgene/index.html) and report on a structured synopsis thereof as of December 1, 2008.
Data on 189 polymorphisms in 84 genes have been included and 36 meta-analyses have been performed. Five gene variants (4 in maternal DNA, one in newborn DNA) have shown nominally significant associations, but all have weak epidemiological credibility.
After publishing this field synopsis, the PTBGene database will be regularly updated to keep track of the evolving evidence base of genetic factors in preterm birth with the goal of promoting knowledge sharing and multicenter collaboration among preterm birth research groups.
我们的目标是制作一份关于早产基因关联的领域概述，并建立一个可公开获取的在线数据库来汇总数据。
我们进行了系统综述和荟萃分析，以确定与早产相关的基因关联。我们建立了一个关于早产基因关联数据的可公开获取的在线数据库，名为PTBGene（http://ric.einstein.yu.edu/ptbgene/index.html），并报告截至2008年12月1日的结构化概述。
已纳入84个基因中189个多态性的数据，并进行了36项荟萃分析。五个基因变异（4个在母体DNA中，1个在新生儿DNA中）显示出名义上显著的关联，但所有这些关联的流行病学可信度都较低。
发布此领域概述后，PTBGene数据库将定期更新，以跟踪早产遗传因素不断发展的证据基础，目标是促进早产研究小组之间的知识共享和多中心合作。
