Putnam P E
Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's, Hospital Medical Center, Cincinnati, OH, USA.
Minerva Gastroenterol Dietol. 2010 Jun;56(2):139-57.
Eosinophilic esophagitis (EoE) is a chronic, eosinophil-predominant inflammatory condition that can affect esophageal mucosa at any age. Distinguished from gastroesophageal reflux disease in the mid 1990's, it has seemed to be increasingly prevalent, and is usually a manifestation of food allergy. The endoscopic and histologic features are well described. The clinical manifestations vary considerably by age, with adolescents and adults complaining primarily of dysphagia. Younger children may present with pain, vomiting, other evidence for food allergy, or feeding difficulties. Treatment options include swallowed (non-systemic) steroids and dietary antigen elimination, and must be maintained indefinitely due to the extremely high rate of recurrence off therapy. The complications of untreated disease include fibrosis of the esophageal lamina propria and stricture formation that result in chronic dysphagia, risking food impaction and perforation.
嗜酸性食管炎（EoE）是一种以嗜酸性粒细胞为主的慢性炎症性疾病，可在任何年龄影响食管黏膜。自20世纪90年代中期与胃食管反流病区分开来后，其发病率似乎日益上升，通常是食物过敏的一种表现。内镜和组织学特征已有详尽描述。临床表现因年龄而异，青少年和成年人主要诉说吞咽困难。年幼儿童可能表现为疼痛、呕吐、其他食物过敏证据或喂养困难。治疗选择包括吞咽（非全身性）类固醇和饮食抗原消除，由于治疗停药后的复发率极高，必须无限期维持治疗。未经治疗的疾病并发症包括食管固有层纤维化和狭窄形成，导致慢性吞咽困难，有食物嵌塞和穿孔的风险。
