Department of Nutrition, Metabolic diseases, Endocrinology, University of Aix-Marseille 2, 'La Timone' Hospital, Marseille, France.
Eur J Clin Nutr. 2010 Aug;64(8):840-4. doi: 10.1038/ejcn.2010.66. Epub 2010 May 19.
The aim of our study was to determine whether eating behaviors and/or physical activity level may explain contradicting results in adipocytokines levels in anorexia nervosa (AN).
SUBJECTS/METHODS: Fasting levels of circulating adipocytokines (adiponectin, resistin and leptin), insulin, glucose, C-reactive protein, cytokines (tumor necrosis factor-alpha and interleukin (IL)-1beta), body composition and resting energy expenditure were measured in 24 women AN patients and 14 women controls. These parameters were compared according to AN subtypes: 15 patients with restrictive (R-AN) form versus 9 patients with binge/purge (BP-AN) form; 15 patients with hyperactive (H-AN) form versus 9 patients with nonhyperactive (NH-AN) form.
BP-AN patients had significantly higher serum adiponectin levels compared with R-AN patients (P<0.05), and H-AN patients had higher serum leptin and lower serum resistin levels compared with NH-AN patients (P<0.05 for both).
Our study shows specific adipocytokines profiles depending on the subtype of AN: restrictive versus binge/purge and hyperactive versus Nonhyperactive forms. We suggest that these biological signatures could interfere with the outcome of the disease.
本研究旨在确定饮食行为和/或体力活动水平是否可以解释神经性厌食症（AN）患者中存在的脂肪细胞因子水平的矛盾结果。
我们测量了 24 名女性神经性厌食症患者和 14 名女性对照组的空腹循环脂肪细胞因子（脂联素、抵抗素和瘦素）、胰岛素、血糖、C 反应蛋白、细胞因子（肿瘤坏死因子-α和白细胞介素-1β）、身体成分和静息能量消耗。根据 AN 亚型对这些参数进行了比较：15 名限制型（R-AN）患者与 9 名暴食/清泻型（BP-AN）患者；15 名高活跃型（H-AN）患者与 9 名非高活跃型（NH-AN）患者。
BP-AN 患者的血清脂联素水平明显高于 R-AN 患者（P<0.05），H-AN 患者的血清瘦素水平较高，血清抵抗素水平较低，与 NH-AN 患者相比（两者均为 P<0.05）。
我们的研究表明，根据 AN 的亚型存在特定的脂肪细胞因子特征：限制型与暴食/清泻型和高活跃型与非高活跃型。我们认为这些生物学特征可能会干扰疾病的结果。
