Kouriba B, Traore B, Diemert D, Thera M A, Dolo A, Tounkara A, Doumbo O
Département d'épidémiologie des affections parasitaires, Faculté de médecine, de pharmacie et d'odontostomatologie, Bamako, Mali.
Med Trop (Mars). 2010 Apr;70(2):189-97.
Schistosomiasis remains a major worldwide public health problem in several endemic areas despite implementation of control measures. Vaccination would be an effective, long-term treatment option for future control of schistosomiasis. Although several parasite antigens have been identified as schistosomiasis vaccine candidates, major hurdles must still be overcome to develop a vaccine suitable for clinical trials in the field. Better understanding of immune responses to Schistosoma infection in both animal models and humans suggests that development of a vaccine is possible. The purpose of this review is to summarize the mechanisms of protective immunity against Schistosoma infection and to provide perspective on the development of a vaccine.
尽管实施了控制措施，但血吸虫病在几个流行地区仍然是一个重大的全球公共卫生问题。疫苗接种将是未来控制血吸虫病的一种有效、长期的治疗选择。虽然已确定几种寄生虫抗原作为血吸虫病疫苗候选物，但要开发一种适合现场临床试验的疫苗仍必须克服主要障碍。对动物模型和人类中血吸虫感染免疫反应的更好理解表明，开发疫苗是有可能的。本综述的目的是总结针对血吸虫感染的保护性免疫机制，并为疫苗开发提供前景展望。
