MEG Center, Department of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Headache. 2010 Jun;50(6):1005-16. doi: 10.1111/j.1526-4610.2010.01674.x. Epub 2010 May 7.
To investigate the functional abnormalities of the motor cortices in children with migraine using magnetoencephalography (MEG) and a finger-tapping task.
Cortical hyperexcitability has been reported in adults with migraine using MEG. Many children with migraine report difficulty with motor functioning. There is no report on motor-evoked magnetic activation in children with migraine using MEG and the latest signal processing methods.
Ten children with migraine (all female, 9 right-handed and 1 left-handed, aged 13-17 years) and 10 age- and gender-matched healthy children were studied with a 275-channel MEG system. After hearing a unilateral, randomly presented sound cue (500 Hz, 30 milliseconds square tone), each subject immediately performed a brisk index finger tapping with either the right or the left index finger. The auditory stimuli consisted of 200 trials of square tone, 100 trials per ear, randomly distributed. The latency and amplitude of neuromagnetic responses were analyzed with averaged waveforms. Neuromagnetic sources were estimated using synthetic aperture magnetometry (SAM). SAM images were normalized for each participant for group comparison.
In comparison with healthy children, children with migraine had prolonged latency of motor-evoked magnetic response in the right hemispheres during left finger movement (62.33 +/- 34.55 milliseconds vs 34.9 +/- 17.29 milliseconds, P < .05). In addition, children with migraine had stronger activation in the motor cortex during right finger movement (8097.46 +/- 5168.99 vs 4697.54 +/- 3194.74, P < .05).
The results suggest that there are neurophysiological changes in the motor cortices of children with migraine that can be measured with neuromagnetic imaging techniques. The findings expand the ability to study the cerebral mechanisms of migraine using MEG and may facilitate the development of new therapeutic strategies in migraine treatment via alterations in cortical excitability.
利用脑磁图（MEG）和手指敲击任务研究偏头痛儿童运动皮质的功能异常。
利用 MEG 报道称偏头痛患者皮质兴奋性过高。许多偏头痛儿童报告运动功能障碍。利用 MEG 和最新信号处理方法，尚未有偏头痛儿童运动诱发电磁激活的报告。
使用 275 通道 MEG 系统对 10 名偏头痛儿童（均为女性，9 名右利手，1 名左利手，年龄 13-17 岁）和 10 名年龄和性别匹配的健康儿童进行研究。每个儿童在听到单侧、随机呈现的声音提示（500 Hz，30 毫秒方波）后，立即用右手或左手食指轻快敲击。听觉刺激由 200 次方波组成，每耳 100 次，随机分布。使用平均波形分析神经磁响应的潜伏期和振幅。使用合成孔径磁定位法（SAM）估计神经磁源。为了进行组间比较，对每个参与者的 SAM 图像进行归一化。
与健康儿童相比，偏头痛儿童在左侧手指运动时右侧半球运动诱发电磁反应潜伏期延长（62.33±34.55 毫秒 vs 34.9±17.29 毫秒，P<.05）。此外，偏头痛儿童在右侧手指运动时运动皮质激活更强（8097.46±5168.99 伏 vs 4697.54±3194.74 伏，P<.05）。
研究结果表明，偏头痛儿童运动皮质存在神经生理变化，可通过神经磁成像技术测量。这些发现扩展了使用 MEG 研究偏头痛脑机制的能力，并可能通过改变皮质兴奋性来促进偏头痛治疗新治疗策略的发展。
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