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多频神经磁信号揭示偏头痛中皮质兴奋性的空间异质性

Spatial Heterogeneity of Cortical Excitability in Migraine Revealed by Multifrequency Neuromagnetic Signals.

作者信息

Xiang Jing, Leiken Kimberly, Degrauw Xinyao, Kay Benjamin, Fujiwara Hisako, Rose Douglas F, Allen Janelle R, Kacperski Joanne E, O'Brien Hope L, Kabbouche Marielle A, Powers Scott W, Hershey Andrew D

机构信息

MEG Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, Ohio.

MEG Center, Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

出版信息

J Pain. 2016 Jun;17(6):694-706. doi: 10.1016/j.jpain.2016.02.009. Epub 2016 Mar 10.

DOI:10.1016/j.jpain.2016.02.009
PMID:26970516
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4885770/
Abstract

UNLABELLED

To investigate the spatial heterogeneity of cortical excitability in adolescents with migraine, magnetoencephalography (MEG) recordings at a sampling rate of 6,000 Hz were obtained from 35 adolescents with an acute migraine and 35 age- and sex-matched healthy control participants during an auditory-motor task. Neuromagnetic activation from low- to high-frequency ranges (5-1,000 Hz) was measured at sensor and source levels. The heterogeneity of cortical excitability was quantified within each functional modality (auditory vs motor) and hemispherical lateralization. MEG data showed that high-frequency, not low-frequency neuromagnetic signals, showed heterogeneous cortical activation in migraine subjects compared with control participants (P < .001). The alteration of the heterogeneity of cortical excitability in migraine subjects was independent of age and sex. The degree of the neuromagnetic heterogeneity of cortical activation was significantly correlated with headache frequency (r = .71, P < .005). The alteration of cortical excitability in migraine subjects was spatially heterogeneous and frequency dependent, which previously has not been reported. The finding may be critical for developing spatially targeted therapeutic strategies for normalizing cortical excitability with the purpose of reducing headache attacks.

PERSPECTIVE

This article presents a new approach to quantitatively measure the spatial heterogeneity of cortical excitability in adolescents with migraine using MEG signals in a frequency range of 5 to 1,000 Hz. The characteristics of the location and degree of cortical excitability may be critical for spatially targeted treatment for migraine.

摘要

未标注

为研究偏头痛青少年皮质兴奋性的空间异质性，在一项听觉-运动任务期间，以6000赫兹的采样率对35名急性偏头痛青少年和35名年龄及性别匹配的健康对照参与者进行了脑磁图（MEG）记录。在传感器和源水平测量了从低频到高频范围（5 - 1000赫兹）的神经磁激活。在每个功能模式（听觉与运动）和半球侧化内对皮质兴奋性的异质性进行了量化。MEG数据显示，与对照参与者相比，偏头痛患者的高频而非低频神经磁信号显示出皮质激活的异质性（P <.001）。偏头痛患者皮质兴奋性异质性的改变与年龄和性别无关。皮质激活的神经磁异质性程度与头痛频率显著相关（r =.71，P <.005）。偏头痛患者皮质兴奋性的改变在空间上是异质的且与频率相关，这在以前尚未有报道。这一发现对于制定旨在通过使皮质兴奋性正常化以减少头痛发作的空间靶向治疗策略可能至关重要。

观点

本文提出了一种新方法，使用5至1000赫兹频率范围内的MEG信号定量测量偏头痛青少年皮质兴奋性的空间异质性。皮质兴奋性的位置和程度特征对于偏头痛的空间靶向治疗可能至关重要。

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