Sturrock R R
Department of Anatomy, University Dundee, Scotland, U.K.
Anat Anz. 1991;172(2):123-8.
The numbers of neurons and glia in the supraoptic nucleus were estimated in mice aged 6, 25, 28 and 31 months. There were no significant variations in the number of neurons or in the number of glia with age. Measurement of neuronal and glial nuclear diameters at 6, 12, 15, 22, 25, 28, and 31 months showed a steady decrease in neuronal nuclear diameter from 9.2 +/- 0.3 microns at 6 months to 8.3 +/- 0.1 microns at 22 months followed by an increase in diameter between 25 and 31 months to 9.8 +/- 0.1 microns. There was no significant variation in glial nuclear diameter (mean 6 microns) with age. Neuronal Nissl substance decreased with age but lipofuscin accumulation was not a prominent feature of ageing supraoptic neurons.
对6、25、28和31月龄小鼠视上核中的神经元和神经胶质细胞数量进行了估算。神经元数量或神经胶质细胞数量均未随年龄出现显著变化。对6、12、15、22、25、28和31月龄小鼠的神经元和神经胶质细胞核直径进行测量，结果显示神经元核直径从6月龄时的9.2±0.3微米稳步下降至22月龄时的8.3±0.1微米，随后在25至31月龄之间直径又增加至9.8±0.1微米。神经胶质细胞核直径（平均6微米）未随年龄出现显著变化。神经元尼氏物质随年龄减少，但脂褐素积累并非衰老视上核神经元的显著特征。
