Michael G. DeGroote School of Medicine, Faculty of Medicine, McMaster University, Hamilton, ON.
J Cutan Med Surg. 2010 May-Jun;14(3):105-14. doi: 10.2310/7750.2010.09027.
Whereas several literature reviews have discussed the role of excipients in drug-related reactions, no article has focused specifically on those found in oral dermatologic medications.
The Compendium of Pharmaceuticals and Specialties (CPS) was used to reference the inert ingredients found in oral dermatologic medications. An extensive literature review was subsequently conducted using PubMed and MEDLINE to document adverse reactions to these excipients.
Sixty-three oral dermatologic medications were reviewed. Lactose was commonly used as a filler. Several medications indicated that they were dye, tartrazine, or gluten free. Three medications were found to contain soybean oil and one was found to contain peanut oil.
Although there are documented reactions to excipients in other products in the literature, few reports outline reactions to excipients in oral dermatologic medications. Whether this low frequency is accurate or whether it is due to a lack of reporting remains unknown. If the latter reasoning is correct, dermatologists must be more aware of these possible reactions. This article serves as a reference guide for dermatologists to aid in prescribing medications to individuals with known sensitivities and to assist in working up patients with suspected reactions to inert ingredients.
虽然已有几篇文献综述讨论了赋形剂在药物相关反应中的作用，但尚无专门针对口腔皮肤科药物中赋形剂的文章。
《药品专论大全》（CPS）被用来参考口腔皮肤科药物中的惰性成分。随后，使用 PubMed 和 MEDLINE 进行了广泛的文献综述，以记录这些赋形剂的不良反应。
共审查了 63 种口腔皮肤科药物。乳糖通常用作填充剂。一些药物表明它们不含染料、酒石黄或麸质。三种药物中含有大豆油，一种药物中含有花生油。
尽管文献中有其他产品中赋形剂的相关反应记录，但很少有报告概述口腔皮肤科药物中赋形剂的反应。这种低频率是准确的，还是由于缺乏报告尚不清楚。如果后一种推理是正确的，皮肤科医生必须更加意识到这些可能的反应。本文旨在为皮肤科医生提供参考指南，以帮助为已知敏感人群开具药物，并协助处理疑似对惰性成分过敏的患者。
