亚硫酸盐的不良反应。
Adverse reactions to sulfites.
作者信息
Yang W H, Purchase E C
出版信息
CMAJ. 1985 Nov 1;133(9):865-7, 880.
Sulfites are widely used as preservatives in the food and pharmaceutical industries. In the United States more than 250 cases of sulfite-related adverse reactions, including anaphylactic shock, asthmatic attacks, urticaria and angioedema, nausea, abdominal pain and diarrhea, seizures and death, have been reported, including 6 deaths allegedly associated with restaurant food containing sulfites. In Canada 10 sulfite-related adverse reactions have been documented, and 1 death suspected to be sulfite-related has occurred. The exact mechanism of sulfite-induced reactions is unknown. Practising physicians should be aware of the clinical manifestations of sulfite-related adverse reactions as well as which foods and pharmaceuticals contain sulfites. Cases should be reported to health officials and proper advice given to the victims to prevent further exposure to sulfites. The food industry, including beer and wine manufacturers, and the pharmaceutical industry should consider using alternative preservatives. In the interim, they should list any sulfites in their products.
亚硫酸盐在食品和制药行业中被广泛用作防腐剂。在美国，已报告了250多起与亚硫酸盐相关的不良反应案例，包括过敏性休克、哮喘发作、荨麻疹和血管性水肿、恶心、腹痛和腹泻、癫痫发作及死亡，其中6例死亡据称与含有亚硫酸盐的餐厅食物有关。在加拿大，已记录了10起与亚硫酸盐相关的不良反应，并且发生了1例疑似与亚硫酸盐相关的死亡。亚硫酸盐引发反应的确切机制尚不清楚。执业医师应了解与亚硫酸盐相关的不良反应的临床表现，以及哪些食品和药品含有亚硫酸盐。应向卫生官员报告此类案例，并向受害者提供适当建议，以防止其进一步接触亚硫酸盐。包括啤酒和葡萄酒制造商在内的食品行业以及制药行业应考虑使用替代防腐剂。在此期间，它们应在产品中列出任何亚硫酸盐成分。
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