视杆和视锥细胞主导的视网膜中的环核苷酸。

Cyclic nucleotides in rod- and cone-dominant retinas.

作者信息

Farber D B, Chase D G, Lolley R N

机构信息

Jules Stein Eye Institute University of California, Los Angeles, CA 90024 USA; Developmental Neurology Laboratory, V.A. Medical Center Sepulveda, California 91343 USA.

出版信息

Neurochem Int. 1980;1C:327-36. doi: 10.1016/0197-0186(80)90070-4.

DOI:10.1016/0197-0186(80)90070-4

PMID:20487745

Abstract

Rod-and cone-dominant retinas differ in their relative content of cyclic AMP and cyclic GMP. Cyclic GMP is concentrated in retinas dominated by rods and is responsive to light; cyclic AMP is enriched in those having a majority of cones. Light reduces by about 50% the content of cyclic AMP in cone-dominant retinas, but the levels of cyclic GMP are affected only minimally. Microdissection of rod-dominant retinas shows that most of the cyclic GMP is localized in photoreceptor cells whereas cyclic AMP is evenly distributed throughout the retina. In contrast, our studies of cyclic nucleotides and the morphological changes that occur in cone visual cells of the ground squirrel retina, during hibernation and iodoacetate-induced cone degeneration, suggest that cyclic AMP is localized in cone visual cells. By analogy with the rod system, cyclic AMP may modulate the intracellular metabolism of cones.

摘要

视杆细胞和视锥细胞主导的视网膜在环磷酸腺苷（cAMP）和环磷酸鸟苷（cGMP）的相对含量上存在差异。cGMP集中在视杆细胞主导的视网膜中，且对光有反应；cAMP在视锥细胞占多数的视网膜中含量丰富。光可使视锥细胞主导的视网膜中的cAMP含量降低约50%，但cGMP水平仅受到极小的影响。对视杆细胞主导的视网膜进行显微解剖显示，大部分cGMP定位于光感受器细胞，而cAMP则均匀分布于整个视网膜。相比之下，我们对环核苷酸以及地松鼠视网膜视锥视觉细胞在冬眠和碘乙酸诱导的视锥细胞退化过程中发生的形态变化的研究表明，cAMP定位于视锥视觉细胞。类比视杆系统，cAMP可能调节视锥细胞的细胞内代谢。