大脑中的多胺代谢与功能

Polyamine metabolism and function in brain.

作者信息

Seiler N

机构信息

Centre de Recherche Merrell International, 16 rue d'Ankara, 67084 Strasbourg Cedex, France.

出版信息

Neurochem Int. 1981;3(2):95-110. doi: 10.1016/0197-0186(81)90027-9.

DOI:10.1016/0197-0186(81)90027-9

PMID:20487812

Abstract

Putrescine, spermidine and spermine are simple alipathic polycations of ubiquitous occurrence. The pathways of biosynthesis and catabolism, and changes of the concentrations of these compounds in brain under various conditions are discussed. The pharmacological properties of the polyamines have not yet revealed functions which are characteristic only for the CNS, but preliminary evidence suggests structural roles in membranes and a modulatory function in certain neuronal systems.

摘要

腐胺、亚精胺和精胺是普遍存在的简单脂肪族多阳离子。本文讨论了它们的生物合成和分解代谢途径，以及在各种条件下大脑中这些化合物浓度的变化。多胺的药理特性尚未揭示仅对中枢神经系统具有特征性的功能，但初步证据表明其在膜中具有结构作用，并在某些神经元系统中具有调节功能。