多胺在卵巢衰老和疾病中的作用。

Polyamines in Ovarian Aging and Disease.

机构信息

State Key Laboratory of Swine and Poultry Breeding Industry, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China.

Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Agricultural University, Chengdu 611130, China.

出版信息

Int J Mol Sci. 2023 Oct 18;24(20):15330. doi: 10.3390/ijms242015330.

DOI:10.3390/ijms242015330

PMID:37895010

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10607840/

Abstract

Ovarian aging and disease-related decline in fertility are challenging medical and economic issues with an increasing prevalence. Polyamines are a class of polycationic alkylamines widely distributed in mammals. They are small molecules essential for cell growth and development. Polyamines alleviate ovarian aging through various biological processes, including reproductive hormone synthesis, cell metabolism, programmed cell death, etc. However, an abnormal increase in polyamine levels can lead to ovarian damage and promote the development of ovarian disease. Therefore, polyamines have long been considered potential therapeutic targets for aging and disease, but their regulatory roles in the ovary deserve further investigation. This review discusses the mechanisms by which polyamines ameliorate human ovarian aging and disease through different biological processes, such as autophagy and oxidative stress, to develop safe and effective polyamine targeted therapy strategies for ovarian aging and the diseases.

摘要

卵巢衰老和与生育能力相关的疾病下降是具有挑战性的医学和经济问题，其发病率正在不断上升。多胺是一类广泛存在于哺乳动物中的多阳离子碱性胺。它们是小分子，对细胞生长和发育至关重要。多胺通过多种生物学过程缓解卵巢衰老，包括生殖激素合成、细胞代谢、程序性细胞死亡等。然而，多胺水平的异常增加会导致卵巢损伤，并促进卵巢疾病的发展。因此，多胺长期以来一直被认为是衰老和疾病的潜在治疗靶点，但它们在卵巢中的调节作用值得进一步研究。本综述讨论了多胺通过不同的生物学过程（如自噬和氧化应激）改善人类卵巢衰老和疾病的机制，以开发安全有效的多胺靶向治疗策略，用于卵巢衰老和相关疾病。