精神药物对促甲状腺激素释放激素（TRH）反应的影响。

The effect of psychotropic drugs on the TSH-response to thyroliberin (TRH).

作者信息

Lamberg B A, Linnoila M, Fogelholm R, Olkinuora M, Kotilainen P, Saarinen P

出版信息

Neuroendocrinology. 1977;24(2):90-7. doi: 10.1159/000122700.

PMID:204879

Abstract

The effect of chlorpromazine (CPZ), thioridazine (TR), L-dopa, fusaric acid (FA), pimozide (PZ) and propranolol (P) in the i.v. thyrotropin-releasing hormone (TRH) stimulation test was studied in 75 subjects. It was found that chronic treatment with CPZ, TR and L-dopa inhibits the response to TRH. FA may to some extent counteract the effect of L-dopa. The results indicate that the response of the pituitary to TRH as regards the secretion of TSH is mainly regulated by norepinephrinergic alpha-receptors.

摘要

在75名受试者中研究了氯丙嗪（CPZ）、硫利达嗪（TR）、左旋多巴、富马酸（FA）、匹莫齐特（PZ）和普萘洛尔（P）对静脉注射促甲状腺激素释放激素（TRH）刺激试验的影响。发现长期使用CPZ、TR和左旋多巴会抑制对TRH的反应。FA可能在一定程度上抵消左旋多巴的作用。结果表明，垂体对TRH刺激的促甲状腺激素分泌反应主要受去甲肾上腺素能α受体调节。