Sanjeeva Reddy T, Ramakrishnan C V
Department of Biochemistry, Faculty of Science, M.S. University of Baroda, Baroda-390 002 India.
Neurochem Int. 1982;4(6):495-9. doi: 10.1016/0197-0186(82)90038-9.
Studies were made of the effects of maternal thiamine deficiency on rat whole brain, gray matter and white matter lipids. Mothers were fed a high protein diet (controls) or thiamine deficient high protein diet (thiamine deficient, TD) from 14th day of gestation through lactation. An additional group (pair fed control, PFC) was pair fed with the thiamine deficient group. The TD pups started showing symptoms of abnormalities in posture, arched back and hind limb paralysis from 16th day of lactation. Significant deficits were found in body weight and brain weight of TD and PFC pups. But the deficits seem to be more in the former group. Significant deficits were observed with regard to the concentration of lipids such as galactolipids, phospholipids and plasmalogens in the whole brain of TD and PFC pups at 21 days of age. Additional deficits were also found in the concentration of cholesterol in PFC pups. Gray matter lipids from TD pups seem to be completely spared. However, deficits were found in galactolipid and ganglioside concentrations in PFC pups. The deficits found in the concentration of different lipids in white matter are similar to those observed in whole brain. These results suggest that the effects of thiamine deficiency may be partly due to resultant growth retardation and partly due to the deficiency of thiamine per se.
研究了母体硫胺素缺乏对大鼠全脑、灰质和白质脂质的影响。从妊娠第14天到哺乳期，给母鼠喂食高蛋白饮食（对照组）或硫胺素缺乏的高蛋白饮食（硫胺素缺乏组，TD）。另外一组（配对喂食对照组，PFC）与硫胺素缺乏组进行配对喂食。TD组幼崽从哺乳期第16天开始出现姿势异常、弓背和后肢麻痹的症状。TD组和PFC组幼崽的体重和脑重均出现显著不足。但前一组的不足似乎更明显。在21日龄时，TD组和PFC组幼崽全脑中半乳糖脂、磷脂和缩醛磷脂等脂质的浓度出现显著不足。PFC组幼崽的胆固醇浓度也发现有额外不足。TD组幼崽的灰质脂质似乎完全未受影响。然而，PFC组幼崽的半乳糖脂和神经节苷脂浓度出现不足。白质中不同脂质浓度的不足与全脑中观察到的情况相似。这些结果表明，硫胺素缺乏的影响可能部分归因于由此导致的生长迟缓，部分归因于硫胺素本身的缺乏。
