Ikeda M, Hirata Y, Fujita K, Shinzato M, Takahashi H, Yagyu S, Nagatsu T
Laboratory of Cell Physiology, Department of Life Chemistry, Graduate School at Nagatsuta, Tokyo Institute of Technology, Yokohama 227, Japan.
Neurochem Int. 1984;6(4):509-12. doi: 10.1016/0197-0186(84)90122-0.
By use of in vivo voltammetry technique, in vivo release of dopamine and serotonin in the striatum under stress was found to be more prominent in spontaneously hypertensive rats (SHR) at 4 weeks of age than in control Wistar-Kyoto rats (WKY). Simultaneously, a greater activation of tyrosine hydroxylase in the striatum was demonstrated in SHR than in WKY. These results indicate that SHR is more susceptible to stress in the central monoaminergic neurons than WKY.
通过使用体内伏安法技术，发现4周龄的自发性高血压大鼠（SHR）在应激状态下纹状体中多巴胺和5-羟色胺的体内释放比对照Wistar-Kyoto大鼠（WKY）更为显著。同时，与WKY相比，SHR纹状体中酪氨酸羟化酶的激活程度更高。这些结果表明，与WKY相比，SHR中枢单胺能神经元对应激更敏感。
