Orthopaedic Surgery Department, Assistance Publique Timone Children's Hospital, Marseille Hospitals Group, 264, rue St-Pierre, 13385 Marseille cedex 5, France.
Orthop Traumatol Surg Res. 2010 May;96(3):310-3. doi: 10.1016/j.otsr.2009.12.007. Epub 2010 Apr 28.
We report the case of a 7-year-old girl presenting with giant cell tumor (GCT) of the index finger, complicated by lung metastases. Index disarticulation, pulmonary metastasectomy and chemotherapy failed to produce a cure, and the child died at the age of 8 years after 1 year's evolution. The pulmonary metastases were discovered following hypoxia during initial biopsy. A review of the literature shows this observation to be original, in terms of the patient's age and of the location, onset and fatal outcome of metastasis. The hypoxic episode complicating biopsy raises the issue of early screening for lung metastases in GCT. Pulmonary dissemination of GCT is of severe prognosis.
我们报告了一例 7 岁女孩,患有食指巨细胞瘤(GCT),并伴有肺部转移。指数关节离断、肺转移瘤切除术和化疗都未能治愈,患儿在 1 年的病程后 8 岁时死亡。在初次活检时因缺氧发现肺部转移。文献复习显示,就患者的年龄、转移的位置、发病和致命结局而言,这一观察结果是新颖的。活检时缺氧的并发症引发了对 GCT 肺转移早期筛查的问题。GCT 的肺部播散预后严重。