Stock C, Veyrier M, Magnin-Verschelde S, Duband S, Lavocat M-P, Teyssier G, Berthelot P
Service de réanimation néonatale et pédiatrique, centre hospitalier universitaire de Saint-Étienne, hopital Nord, avenue Albert-Raimond, 42270 Saint-Priest-en-Jarez, France.
Arch Pediatr. 2010 Oct;17(10):1455-9. doi: 10.1016/j.arcped.2010.04.012. Epub 2010 May 21.
Aspergillus is a ubiquitous fungus that can cause primary cutaneous aspergillosis in extremely low-birth-weight (ELBW) neonates, then be invasive and lead to death. ELBW neonates are particularly at risk because of decreased qualitative immune defenses and defects in the skin barrier. Broad-spectrum antimicrobial therapy and corticosteroids, often used in these patients, contribute to increased risk. We present a fatal case of primary cutaneous aspergillosis complicated with invasive aspergillosis, confirmed by autopsy, in an ELBW infant. The source of contamination was probably non-sterile disposable latex gloves used for neonatal care. The early recognition of this source led to its eviction for other hospitalized ELBW infants and no outbreak was observed.
曲霉菌是一种广泛存在的真菌，可在极低出生体重（ELBW）新生儿中引起原发性皮肤曲霉病，进而侵袭并导致死亡。由于定性免疫防御功能下降和皮肤屏障缺陷，ELBW新生儿尤其面临风险。这些患者常用的广谱抗菌治疗和皮质类固醇会增加风险。我们报告一例ELBW婴儿原发性皮肤曲霉病并发侵袭性曲霉病的致死病例，尸检确诊。污染源可能是用于新生儿护理的非无菌一次性乳胶手套。对该污染源的早期识别导致其被其他住院的ELBW婴儿停用，未观察到疫情暴发。
