双环[3.3.0]辛烷衍生物的合成及作为二肽基肽酶 4 抑制剂用于治疗 2 型糖尿病的生物学评价。
Synthesis and biological evaluation of bicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes.
机构信息
Shanghai Hengrui Pharmaceuticals Co., Ltd, Shanghai, China.
出版信息
Bioorg Med Chem Lett. 2010 Jun 15;20(12):3521-5. doi: 10.1016/j.bmcl.2010.04.138. Epub 2010 May 18.
PMID:20488704
Abstract
A series of novel bicyclo[3.3.0]octane derivatives have been synthesized and found to be dipeptidyl peptidase 4 (DPP-4) inhibitors. Compounds 10a and 10b demonstrate good efficacies in oral glucose tolerance tests.
摘要
已合成了一系列新型双环[3.3.0]辛烷衍生物，并发现它们是二肽基肽酶 4（DPP-4）抑制剂。化合物 10a 和 10b 在口服葡萄糖耐量试验中显示出良好的疗效。
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