Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15261, USA.
J Heart Lung Transplant. 2010 Aug;29(8):838-40. doi: 10.1016/j.healun.2010.03.017. Epub 2010 May 20.
With the increasing availability of pigs genetically engineered to protect their tissues from the human immune response, research into xenotransplantation is progressing steadily. One potential route to the clinic would be the use of a pig heart as a bridge to allotransplantation. This would only be ethical if the outcome was realistically estimated to be as good as, or better than, bridging with a mechanical device. The experimental results that would be required to warrant consideration of a clinical trial and the patients in whom bridging with a xenograft might be considered preferable to a mechanical device are discussed.
随着基因工程猪的组织可以免受人体免疫反应的保护，越来越多，异种移植的研究也在稳步推进。一种潜在的临床途径是使用猪的心脏作为同种异体移植的桥梁。只有当结果被现实地估计为与使用机械装置一样好或更好时，这种方法才具有伦理意义。讨论了为临床试验考虑所需的实验结果以及哪些患者可能更倾向于使用异种移植物而不是机械装置进行桥接。
