Department of Ophthalmology, University of Ottawa and The Ottawa Hospital, Ottawa, Ontario, Canada.
Ophthalmic Plast Reconstr Surg. 2010 May-Jun;26(3):147-52. doi: 10.1097/IOP.0b013e3181b80b65.
To describe the histopathologic findings in a series of eyelid basal cell carcinomas removed from patients with basal cell nevus syndrome.
Retrospective case series of 5 patients with basal cell nevus syndrome identified from our oculoplastics service. The systemic and ophthalmic features were reviewed, and a retrospective histopathologic analysis of all available previously excised eyelid lesions was performed. The pertinent published literature on basal cell nevus syndrome and eyelid basal cell carcinoma was reviewed.
A total of 26 eyelid lesions were examined histopathologically. Twenty-three of these lesions were basal cell carcinomas. The infundibulocystic variant of basal cell carcinoma was identified most commonly (57%).
Eyelid basal cell carcinomas in patients with basal cell nevus syndrome were commonly of the infundibulocystic variety in our series. Infundibulocystic basal cell carcinomas, which can be clinically indistinguishable from the more common forms, are thought to be less aggressive than other types of basal cell carcinoma and are a reassuring histopathologic diagnosis. It is important for the ophthalmologist and pathologist to be aware of infundibulocystic basal cell carcinomas, as they are more common in patients with basal cell nevus syndrome and may be a clue to the diagnosis of this autosomal dominant cancer-predisposition syndrome or other associated syndromes. To our knowledge, this variant of basal cell carcinoma has not been previously discussed in the ophthalmic literature.
描述基底细胞痣综合征患者切除的一系列眼睑基底细胞癌的组织病理学发现。
对我们眼整形科服务中确定的 5 例基底细胞痣综合征患者进行回顾性病例系列研究。回顾了系统和眼科特征，并对所有先前切除的眼睑病变进行了回顾性组织病理学分析。回顾了关于基底细胞痣综合征和眼睑基底细胞癌的相关文献。
共检查了 26 个眼睑病变。其中 23 个为基底细胞癌。基底细胞癌的囊状漏斗状变体最常见（57%）。
在我们的系列中，基底细胞痣综合征患者的眼睑基底细胞癌通常为囊状漏斗状。在临床上与更常见的形式难以区分的囊状漏斗状基底细胞癌，被认为比其他类型的基底细胞癌侵袭性更小，是一种令人放心的组织病理学诊断。眼科医生和病理学家了解囊状漏斗状基底细胞癌很重要，因为它们在基底细胞痣综合征患者中更为常见，并且可能是诊断这种常染色体显性癌症易感性综合征或其他相关综合征的线索。据我们所知，这种基底细胞癌变体以前尚未在眼科文献中讨论过。
