T-cell reactivity to purified lipophosphoglycan from Leishmania major: a model for analysis of the cellular immune response to microbial carbohydrates.

The major macromolecule on the surface of Leishmania major promastigotes is a lipophosphoglycan (LPG). This glycoconjugate plays a key role in determining infectivity and survival of parasites in the mammalian host cell. In addition, L. major LPG is able to induce a host-protective immune response. In this article, we summarise the evidence for recognition of highly purified LPG by T cells and we discuss the potential mechanisms of T-cell stimulation by this non-protein antigen.