Center for Wireless Communications and Signal Processing Research, Department of Electrical and Computer Engineering & Department of Biological Sciences, New Jersey Institute of Technology, 323 King Blvd, Newark, NJ 07102, USA.
Chem Biodivers. 2010 May;7(5):1111-23. doi: 10.1002/cbdv.200900315.
Fault diagnosis engineering is a key component of modern industrial facilities and complex systems, and has gone through considerable developments in the past few decades. In this paper, the principles and concepts of molecular fault diagnosis engineering are reviewed. In this area, molecular intracellular networks are considered as complex systems that may fail to function, due to the presence of some faulty molecules. Dysfunction of the system due to the presence of a single or multiple molecules can ultimately lead to the transition from the normal state to the disease state. It is the goal of molecular fault diagnosis engineering to identify the critical components of molecular networks, i.e., those whose dysfunction can interrupt the function of the entire network. The results of the fault analysis of several signaling networks are discussed, and possible connections of the findings with some complex human diseases are examined. Implications of molecular fault diagnosis engineering for target discovery and drug development are outlined as well.
故障诊断工程是现代工业设施和复杂系统的关键组成部分，在过去几十年中经历了相当大的发展。本文回顾了分子故障诊断工程的原理和概念。在这个领域，细胞内分子网络被认为是复杂的系统，由于存在一些有缺陷的分子，它们可能无法正常工作。由于单个或多个分子的存在，系统功能失调最终可能导致从正常状态向疾病状态的转变。分子故障诊断工程的目标是识别分子网络的关键组件，即那些功能失调会中断整个网络功能的组件。讨论了对几个信号网络的故障分析结果，并检查了这些发现与某些复杂人类疾病的可能联系。还概述了分子故障诊断工程对靶标发现和药物开发的意义。
