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急性结肠憩室出血的自然病史:133 例连续患者的前瞻性研究。

Natural history of acute colonic diverticular bleeding: a prospective study in 133 consecutive patients.

机构信息

Department of Surgery, Grenoble University Hospital, France.

出版信息

Aliment Pharmacol Ther. 2010 Aug;32(3):466-71. doi: 10.1111/j.1365-2036.2010.04362.x. Epub 2010 May 18.

Abstract

BACKGROUND

Bleeding recurrence rate after spontaneous haemostasis of colonic diverticular haemorrhage varies in the literature, and a small minority of patients will require endoscopic, radiological or surgical intervention.

AIM

To study the natural history of colonic diverticular bleeding in consecutive patients.

METHODS

We studied prospectively consecutive patients admitted for colonic diverticular bleeding from 1997 to 2005. Data on age, gender, 30-day mortality, therapeutic modality for bleeding management and subsequent rebleeding were collected.

RESULTS

One hundred and thirty-three patients (mean age 75.7 years) were recruited. Bleeding stopped spontaneously in 123 patients (92.4%). A more interventional approach was necessary in 10 patients. Thirty-day mortality rate for first bleeding was 2.25%. Out of the 123 patients managed conservatively and submitted to an average follow-up of 47.5 months, 17 (13.8%) presented at least one recurrent diverticular bleeding. Spontaneous haemostasis was obtained in all recurrent cases except one, who died. The estimated bleeding recurrence rate was 3.8% at 1 year, 6.9% at 5 years and 9.8% at 10 years.

CONCLUSIONS

The low estimated rebleeding rate and the fact that rebleeding can be treated conservatively in most cases suggest that an aggressive approach with intervention is not justified.

摘要

背景

文献中自发性结肠憩室出血止血后再出血率不一,少数患者需要内镜、放射或手术干预。

目的

研究连续患者结肠憩室出血的自然史。

方法

我们前瞻性地研究了 1997 年至 2005 年因结肠憩室出血入院的连续患者。收集了年龄、性别、30 天死亡率、出血管理的治疗方式和随后再出血的数据。

结果

共招募了 133 名患者(平均年龄 75.7 岁)。123 名患者(92.4%)自发性止血。10 名患者需要更介入性的治疗方法。首次出血的 30 天死亡率为 2.25%。在 123 名接受保守治疗并接受平均 47.5 个月随访的患者中,17 名(13.8%)至少出现一次复发性憩室出血。除 1 例死亡外,所有复发性病例均自发性止血。估计 1 年、5 年和 10 年的出血复发率分别为 3.8%、6.9%和 9.8%。

结论

再出血率估计较低,且大多数情况下复发性出血可保守治疗,这表明干预的积极方法是不合理的。

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