Chowhan Z T, Amaro A A
J Pharm Sci. 1977 Sep;66(9):1249-53. doi: 10.1002/jps.2600660911.
An in vitro model that utilizes everted rat intestinal sacs was evaluated for assessing the absorptivity of several analogs of potential drug substances prior to formulation work and clinical trials. This model not only is a useful qualitative tool for assessing absorptivity of structurally related compounds but also yields some insight into the process involved in drug absorption. Notwithstanding the complexities involved in the absorption processes, the data support the hypothesis that the absorption of organic electrolytes mainly takes place by the partitioning of the unionized species into the lipoidal membranes and then diffusion.
在进行制剂工作和临床试验之前，对一种利用外翻大鼠肠囊的体外模型进行了评估，以测定几种潜在药物类似物的吸收性。该模型不仅是评估结构相关化合物吸收性的有用定性工具，还能让我们对药物吸收过程有所了解。尽管吸收过程存在复杂性，但数据支持这样的假设，即有机电解质的吸收主要通过非离子化形式分配到脂质膜中然后扩散来进行。
