体外血脑屏障：对从大脑分离出的微血管进行研究的十年

The blood-brain barrier in vitro: Ten years of research on microvessels isolated from the brain.

作者信息

Joó F

机构信息

Laboratory of Molecular Neurobiology, Institute of Biophysics, Biological Research Center, Szeged, Hungary.

出版信息

Neurochem Int. 1985;7(1):1-25. doi: 10.1016/0197-0186(85)90002-6.

DOI:10.1016/0197-0186(85)90002-6

PMID:20492893

Abstract

The cerebral microvessels represent a distinctive compartment in the brain with unique physiological, biochemical and morphological properties. The barrier which separates the general circulation from the central nervous system is a complex mechanism that has a relative impermeability to a number of blood-borne substances, but-at the same time-operates with several specific carriers for the various compounds needed in the brain. Morphologically, the presence of tight interendothelial junctions, the paucity of pinocytotic vesicles in the endothelium and the absence of fenestrations are the hallmarks of this barrier.

摘要

脑微血管是大脑中一个独特的部分，具有独特的生理、生化和形态学特性。将体循环与中枢神经系统分隔开的屏障是一种复杂的机制，它对许多血源性物质具有相对不渗透性，但同时又通过几种特定的载体来转运大脑所需的各种化合物。从形态学上讲，内皮细胞间紧密连接的存在、内皮细胞中吞饮小泡的稀少以及窗孔的缺乏是这种屏障的标志。