氨对大鼠脑柠檬酸循环中酶的急性影响。
Acute effects of ammonia on the enzymes of citric acid cycle in rat brain.
作者信息
Ratnakumari L, Subbalakshmi G Y, Murthy C R
机构信息
School of Life Sciences, University of Hyderabad, Hyderabad-500 134 India.
出版信息
Neurochem Int. 1986;8(1):115-20. doi: 10.1016/0197-0186(86)90108-7.
Activities of the enzymes of citric acid cycle were determined along with aspartate and alanine aminotransferases and NADP(+)-isocitrate dehydrogenase in the brains of rats treated with an acute dose of ammonium acetate and compared with those of normal animals. Elevation in the activities of pyruvate, ?-ketoglutarate and succinate dehydrogenases and citrate synthase was observed in hyperammonemic animals. The activities of malate, NADP(+)-isocitrate dehydrogenases and aminotransferases decreased under these conditions. The results suggest that ammonia toxicity might not be due to the depletion of ?-ketoglutarate from citric acid cycle.
测定了急性给予醋酸铵处理的大鼠大脑中柠檬酸循环酶的活性，以及天冬氨酸和丙氨酸转氨酶及NADP(+)-异柠檬酸脱氢酶的活性，并与正常动物的进行比较。在高氨血症动物中观察到丙酮酸、α-酮戊二酸和琥珀酸脱氢酶以及柠檬酸合酶的活性升高。在这些条件下，苹果酸、NADP(+)-异柠檬酸脱氢酶和转氨酶的活性降低。结果表明，氨毒性可能并非由于柠檬酸循环中α-酮戊二酸的消耗所致。
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