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本文引用的文献

1
The biology of chromatin remodeling complexes.染色质重塑复合物的生物学
Annu Rev Biochem. 2009;78:273-304. doi: 10.1146/annurev.biochem.77.062706.153223.
2
Understanding the words of chromatin regulation.理解染色质调控的相关术语。
Cell. 2009 Jan 23;136(2):200-6. doi: 10.1016/j.cell.2009.01.009.
3
Polybromo-1: the chromatin targeting subunit of the PBAF complex.多溴蛋白-1：PBAF复合物的染色质靶向亚基。
Biochimie. 2009 Mar;91(3):309-19. doi: 10.1016/j.biochi.2008.10.019. Epub 2008 Dec 3.
4
Structure of a RSC-nucleosome complex and insights into chromatin remodeling.RSC-核小体复合物的结构及对染色质重塑的见解
Nat Struct Mol Biol. 2008 Dec;15(12):1272-7. doi: 10.1038/nsmb.1524. Epub 2008 Nov 23.
5
BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells.BRD7是一种新型的PBAF特异性SWI/SNF亚基，是胚胎干细胞中靶基因激活和抑制所必需的。
J Biol Chem. 2008 Nov 21;283(47):32254-63. doi: 10.1074/jbc.M806061200. Epub 2008 Sep 22.
6
Architecture of the SWI/SNF-nucleosome complex.SWI/SNF-核小体复合物的结构
Mol Cell Biol. 2008 Oct;28(19):6010-21. doi: 10.1128/MCB.00693-08. Epub 2008 Jul 21.
7
The HSA domain binds nuclear actin-related proteins to regulate chromatin-remodeling ATPases.热稳定抗原（HSA）结构域结合核肌动蛋白相关蛋白以调节染色质重塑ATP酶。
Nat Struct Mol Biol. 2008 May;15(5):469-76. doi: 10.1038/nsmb.1403. Epub 2008 Apr 13.
8
An essential switch in subunit composition of a chromatin remodeling complex during neural development.神经发育过程中染色质重塑复合物亚基组成的关键转变。
Neuron. 2007 Jul 19;55(2):201-15. doi: 10.1016/j.neuron.2007.06.019.
9
Acetylated histone tail peptides induce structural rearrangements in the RSC chromatin remodeling complex.乙酰化组蛋白尾肽诱导RSC染色质重塑复合物中的结构重排。
J Biol Chem. 2007 Jul 20;282(29):20804-8. doi: 10.1074/jbc.C700081200. Epub 2007 May 29.
10
Conformational flexibility in the chromatin remodeler RSC observed by electron microscopy and the orthogonal tilt reconstruction method.通过电子显微镜和正交倾斜重建方法观察到的染色质重塑因子RSC中的构象灵活性。
Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):4913-8. doi: 10.1073/pnas.0700706104. Epub 2007 Mar 13.

SWI/SNF 染色质重塑复合物的结构与功能及其对转录的机制影响。

Structure and function of SWI/SNF chromatin remodeling complexes and mechanistic implications for transcription.

机构信息

Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing 400044, China.

出版信息

Prog Biophys Mol Biol. 2010 Jun-Jul;102(2-3):122-8. doi: 10.1016/j.pbiomolbio.2010.05.001. Epub 2010 May 20.

DOI:10.1016/j.pbiomolbio.2010.05.001
PMID:20493208
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2924208/
Abstract

ATP-dependent chromatin remodeling complexes are specialized protein machinery able to restructure the nucleosome to make its DNA accessible during transcription, replication and DNA repair. During the past few years structural biologists have defined the architecture and dynamics of some of these complexes using electron microscopy, shedding light on the mechanisms of action of these important assemblies. In this paper we review the existing structural information on the SWI/SNF family of the ATP-dependent chromatin remodeling complexes, and discuss their mechanistic implications.

摘要

ATP 依赖的染色质重塑复合物是一种专门的蛋白质机器，能够重塑核小体，使其在转录、复制和 DNA 修复过程中 DNA 可接近。在过去的几年中，结构生物学家使用电子显微镜定义了其中一些复合物的结构和动力学，揭示了这些重要组装体的作用机制。在本文中，我们回顾了 ATP 依赖的染色质重塑复合物 SWI/SNF 家族的现有结构信息，并讨论了它们的机制意义。