Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, Chongqing 400044, China.
Prog Biophys Mol Biol. 2010 Jun-Jul;102(2-3):122-8. doi: 10.1016/j.pbiomolbio.2010.05.001. Epub 2010 May 20.
ATP-dependent chromatin remodeling complexes are specialized protein machinery able to restructure the nucleosome to make its DNA accessible during transcription, replication and DNA repair. During the past few years structural biologists have defined the architecture and dynamics of some of these complexes using electron microscopy, shedding light on the mechanisms of action of these important assemblies. In this paper we review the existing structural information on the SWI/SNF family of the ATP-dependent chromatin remodeling complexes, and discuss their mechanistic implications.
ATP 依赖的染色质重塑复合物是一种专门的蛋白质机器,能够重塑核小体,使其在转录、复制和 DNA 修复过程中 DNA 可接近。在过去的几年中,结构生物学家使用电子显微镜定义了其中一些复合物的结构和动力学,揭示了这些重要组装体的作用机制。在本文中,我们回顾了 ATP 依赖的染色质重塑复合物 SWI/SNF 家族的现有结构信息,并讨论了它们的机制意义。