Larzelere Michele M, Campbell James S, Robertson Marta
Department of Family Medicine, Louisiana State University Health Sciences Center, 200 West Esplanade Avenue, Suite 409, Kenner, LA 70065, USA.
Prim Care. 2010 Jun;37(2):213-36. doi: 10.1016/j.pop.2010.02.002.
Evidence on the use of complementary and alternative medicine (CAM) modalities in the treatment of depression, anxiety, sleep disorders, and attention-deficit/hyperactivity disorder (ADHD) is reviewed. There is strong evidence to support the use of St. John's wort (SJW) in depression, and growing support for the use of omega-3 fatty acids and S-adenosyl-l-methionine as potential adjuncts to conventional therapies. Evidence is insufficient to support the antidepressant benefit of dehydroepiandrosterone, inositol, folate, and saffron. Only kava has high-quality evidence for use in the treatment of anxiety disorders, and its use is discouraged because of safety concerns. There is preliminary supportive evidence for valerian and inositol treatment of anxiety, but SJW and passionflower have achieved little research support. Melatonin is likely to be useful in treating delayed sleep phase, jet lag, or shift work, but there is little evidence for the benefit of valerian compared with placebo. There are currently no evidence-supported CAM treatments for ADHD (zinc and omega-3 fatty acids are reviewed).
本文综述了补充和替代医学（CAM）疗法在治疗抑郁症、焦虑症、睡眠障碍和注意力缺陷多动障碍（ADHD）方面的应用证据。有强有力的证据支持圣约翰草（SJW）用于治疗抑郁症，并且越来越多的证据支持使用ω-3脂肪酸和S-腺苷-L-蛋氨酸作为传统疗法的潜在辅助药物。证据不足以支持脱氢表雄酮、肌醇、叶酸和藏红花的抗抑郁作用。只有卡瓦有高质量的证据支持其用于治疗焦虑症，但由于安全问题不鼓励使用。有初步的支持性证据表明缬草和肌醇可治疗焦虑症，但圣约翰草和西番莲几乎没有研究支持。褪黑素可能有助于治疗睡眠时相延迟、时差反应或轮班工作，但与安慰剂相比，几乎没有证据表明缬草有益。目前没有证据支持的CAM疗法可用于治疗ADHD（对锌和ω-3脂肪酸进行了综述）。
