Suppr超能文献

植物干细胞龛的转录控制。

Transcriptional control of a plant stem cell niche.

机构信息

AG Lohmann, Max Planck Institute for Developmental Biology, D-72076 Tübingen, Germany.

出版信息

Dev Cell. 2010 May 18;18(5):849-61. doi: 10.1016/j.devcel.2010.03.012.

Abstract

Despite the independent evolution of multicellularity in plants and animals, the basic organization of their stem cell niches is remarkably similar. Here, we report the genome-wide regulatory potential of WUSCHEL, the key transcription factor for stem cell maintenance in the shoot apical meristem of the reference plant Arabidopsis thaliana. WUSCHEL acts by directly binding to at least two distinct DNA motifs in more than 100 target promoters and preferentially affects the expression of genes with roles in hormone signaling, metabolism, and development. Striking examples are the direct transcriptional repression of CLAVATA1, which is part of a negative feedback regulation of WUSCHEL, and the immediate regulation of transcriptional repressors of the TOPLESS family, which are involved in auxin signaling. Our results shed light on the complex transcriptional programs required for the maintenance of a dynamic and essential stem cell niche.

摘要

尽管植物和动物的多细胞结构是独立进化的,但它们的干细胞龛的基本组织形式却惊人地相似。在这里,我们报告了 WUSCHEL 的全基因组调控潜力,WUSCHEL 是参考植物拟南芥茎尖分生组织中维持干细胞的关键转录因子。WUSCHEL 通过直接结合到至少 100 个靶启动子中的两个不同 DNA 基序起作用,并且优先影响具有激素信号转导、代谢和发育作用的基因的表达。一个显著的例子是 CLAVATA1 的直接转录抑制,CLAVATA1 是 WUSCHEL 负反馈调节的一部分,以及 TOPLESS 家族转录抑制剂的直接调节,TOPLESS 家族参与生长素信号转导。我们的研究结果揭示了维持动态和必需的干细胞龛所需的复杂转录程序。

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验