Division of Thoracic Surgery, Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, California 94305, USA.
Ann Thorac Surg. 2010 Jun;89(6):S2128-34. doi: 10.1016/j.athoracsur.2010.02.099.
The ideal operative technique for thymectomy in myasthenia gravis remains controversial. Most surgeons perform thymectomy through median sternotomy; more recently, thoracoscopic and robotic approaches have been described. "Extended transcervical thymectomy" is an out-patient procedure that appears less morbid and costly than other approaches. It allows a complete extracapsular thymic resection. Kaplan-Meier complete stable remission rates after transcervical thymectomy are 33% and 35% at 3 and 6 years (higher including patients remaining on single-drug immunosuppression). The major surgical complication rate is 0.7%. We believe that this less morbid and less costly operation is a very reasonable choice in the surgical treatment of myasthenia gravis.
胸腺切除术治疗重症肌无力的理想手术技术仍存在争议。大多数外科医生通过正中胸骨切开术进行胸腺切除术;最近,胸腔镜和机器人方法也有描述。“扩展经颈胸腺切除术”是一种门诊手术,其病态和费用均低于其他方法。它允许进行完整的囊外胸腺切除术。经颈胸腺切除术 3 年和 6 年的 Kaplan-Meier 完全稳定缓解率分别为 33%和 35%(包括仍接受单药免疫抑制治疗的患者,则更高)。主要手术并发症发生率为 0.7%。我们认为,这种病态和费用较低的手术是重症肌无力外科治疗的一个非常合理的选择。