Roche R&D Center China, Shanghai, China.
Bioorg Med Chem Lett. 2010 Jun 15;20(12):3507-10. doi: 10.1016/j.bmcl.2010.04.141. Epub 2010 May 5.
A novel class of HA inhibitors (4a) was identified based on ligand similarity search of known HA inhibitors. Parallel synthesis and further structural modifications resulted in 1-phenyl-cyclopentanecarboxylic acid (4-cyano-phenyl)-methyl-amide 4t as a potent and selective inhibitor to phylogenetic H1 influenza viruses with an EC(50) of 98 nM against H1N1 A/Weiss/43 strain and over 1000-fold selectivity against host MDCK cells.
基于已知的 HA 抑制剂的配体相似性搜索，发现了一类新型的 HA 抑制剂（4a）。通过平行合成和进一步的结构修饰，得到了 1-苯基-环戊烷羧酸（4-氰基-苯基）-甲基-酰胺 4t，它是一种针对进化枝 H1 流感病毒的有效且选择性的抑制剂，对 H1N1 A/Weiss/43 株的 EC50 为 98 nM，对宿主 MDCK 细胞的选择性超过 1000 倍。
