Andolina Jeffrey R, Dilley Kimberley
Children's Memorial Hospital, Chicago, IL 60614, USA.
J Pediatr Hematol Oncol. 2010 Jul;32(5):411-5. doi: 10.1097/MPH.0b013e3181dccd37.
We did a retrospective medical record and echocardiogram review of patients with history of anthracyclines and/or radiation seen in a long-term survivor clinic from 2000-2007.
Three hundred eight out of three hundred seventy (83.2%) patients had received at least 1 screening echocardiogram, and 24/308 (7.8%) patients had an abnormal echocardiogram. Observed risk factors for a future abnormal echocardiogram included anthracycline dose > or =250 mg/m2 and underweight status (BMI <5th%) at follow-up. Age, gender, radiation, anthracycline type, history of relapse, and history of stem cell transplant were not risk factors.
Our results confirm the dose-dependent risk of anthracyclines, and describe a novel association with underweight status.
我们对2000年至2007年在长期幸存者诊所就诊的有蒽环类药物和/或放疗史的患者进行了回顾性病历和超声心动图检查。
370例患者中有308例（83.2%）至少接受过1次筛查性超声心动图检查，其中24/308例（7.8%）患者超声心动图异常。未来超声心动图异常的观察到的危险因素包括蒽环类药物剂量≥250mg/m²以及随访时体重过轻状态（BMI<第5百分位数）。年龄、性别、放疗、蒽环类药物类型、复发史和干细胞移植史不是危险因素。
我们的结果证实了蒽环类药物的剂量依赖性风险，并描述了与体重过轻状态的一种新关联。
