蒽环类药物引起的心脏毒性在体重不足的儿童癌症幸存者中更有可能出现。

Anthracycline-induced cardiac toxicity more likely in underweight childhood cancer survivors.

作者信息

Andolina Jeffrey R, Dilley Kimberley

机构信息

Children's Memorial Hospital, Chicago, IL 60614, USA.

出版信息

J Pediatr Hematol Oncol. 2010 Jul;32(5):411-5. doi: 10.1097/MPH.0b013e3181dccd37.

DOI:10.1097/MPH.0b013e3181dccd37

PMID:20495481

Abstract

BACKGROUND

We did a retrospective medical record and echocardiogram review of patients with history of anthracyclines and/or radiation seen in a long-term survivor clinic from 2000-2007.

OBSERVATIONS

Three hundred eight out of three hundred seventy (83.2%) patients had received at least 1 screening echocardiogram, and 24/308 (7.8%) patients had an abnormal echocardiogram. Observed risk factors for a future abnormal echocardiogram included anthracycline dose > or =250 mg/m2 and underweight status (BMI <5th%) at follow-up. Age, gender, radiation, anthracycline type, history of relapse, and history of stem cell transplant were not risk factors.

CONCLUSIONS

Our results confirm the dose-dependent risk of anthracyclines, and describe a novel association with underweight status.

摘要

背景

我们对2000年至2007年在长期幸存者诊所就诊的有蒽环类药物和/或放疗史的患者进行了回顾性病历和超声心动图检查。

观察结果

370例患者中有308例（83.2%）至少接受过1次筛查性超声心动图检查，其中24/308例（7.8%）患者超声心动图异常。未来超声心动图异常的观察到的危险因素包括蒽环类药物剂量≥250mg/m²以及随访时体重过轻状态（BMI<第5百分位数）。年龄、性别、放疗、蒽环类药物类型、复发史和干细胞移植史不是危险因素。