Li Wan-gui, Tu Qian, Gu Xue-juan
Department of Rehabilitation, Central Hospital of Xianning City, Xianning 437100, China.
Zhongguo Zhen Jiu. 2010 Mar;30(3):200-2.
To explore the clinical effect and mechanism of long snake moxibustion combined with functional exercise for treatment of ankylosing spondylitis in early stage.
Seventy-eight cases of ankylosing spondylitis in early stage were randomly divided into an observation group and a control group, 39 cases in each group. The observation group was treated with long snake moxibustion from Dazhui (GV 14) to Yaoshu (GV 2) combined with functional exercise; the control group was treated with oral administration of Sulfasalazine. The effects of the two groups were observed, and contents of erythrocyte sedimentation rate (ESR), tumor necrosis factor alpha (TNF-alpha), intercellular adhesion molecule-1 (ICAM-1) were tested before and after treatment.
The total effective rate of 89.7% (35/39) in the observation group, was superior to that of 76.9% (30/39) in the control group (P<0.05). The contents of ESR, TNF-alpha, and ICAM-1 showed downtrend after treatment in the both groups (P<0.05, P<0.01), and the observation group decreased more obviously (all P<0.01).
Long snake moxibustion at Governor Vessel combined with functional exercise for treatment of ankylosing spondylitis in early stage, can significantly improve clinical symptoms, decrease the level of serum inflammatory cytokines, and the effect is superior to that of Sulfasalazine oral administration.
探讨长蛇灸结合功能锻炼治疗早期强直性脊柱炎的临床疗效及作用机制。
将78例早期强直性脊柱炎患者随机分为观察组和对照组，每组39例。观察组采用从大椎（GV 14）至腰俞（GV 2）的长蛇灸结合功能锻炼治疗；对照组采用口服柳氮磺胺吡啶治疗。观察两组疗效，并检测治疗前后红细胞沉降率（ESR）、肿瘤坏死因子α（TNF-α）、细胞间黏附分子-1（ICAM-1）的含量。
观察组总有效率为89.7%（35/39），优于对照组的76.9%（30/39）（P<0.05）。两组治疗后ESR、TNF-α、ICAM-1含量均呈下降趋势（P<0.05，P<0.01），且观察组下降更明显（均P<0.01）。
督脉长蛇灸结合功能锻炼治疗早期强直性脊柱炎，能显著改善临床症状，降低血清炎性细胞因子水平，疗效优于口服柳氮磺胺吡啶。
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