巴喷丁。
Bapineuzumab.
机构信息
Stanford University School of Medicine, Stanford Center for Memory Disorders, 300 Pasteur Drive, Room A343, Stanford, CA 94305-5235, USA.
出版信息
Expert Opin Biol Ther. 2010 Jul;10(7):1121-30. doi: 10.1517/14712598.2010.493872.
IMPORTANCE OF THE FIELD
Alzheimer's disease is the leading cause of dementia in the elderly, and there is no disease-modifying therapy yet available. Immunotherapy directed against the beta-amyloid peptide may be capable of slowing the rate of disease progression. Bapineuzumab, an anti-beta-amyloid monoclonal antibody, will be the first such agent to emerge from Phase III clinical trials.
AREAS COVERED IN THIS REVIEW
The primary literature on bapineuzumab from 2009 and 2010 is reviewed in its entirety, along with the literature on AN1792, a first-generation anti-beta-amyloid vaccine, from 2003 to 2009. Other Alzheimer's disease immunotherapeutics currently in development, according to www.clinicaltrials.gov , are also discussed.
WHAT THE READER WILL GAIN
In addition to a critical appraisal of the Phase II trial results for bapineuzumab, this review considers the broader field of immunotherapy for Alzheimer's disease as a whole, including the challenges ahead.
TAKE HOME MESSAGE
Bapineuzumab appears capable of reducing the cerebral beta-amyloid peptide burden in patients with Alzheimer's disease. However, particularly in APOE 4 carriers, its ability to slow disease progression remains uncertain, and vasogenic edema - a dose-limiting and potentially severe adverse reaction - may limit its clinical applicability.
重要性的领域
阿尔茨海默病是老年人痴呆症的主要原因，还没有可用的疾病修饰疗法。针对β-淀粉样肽的免疫疗法可能能够减缓疾病进展的速度。Bapineuzumab，一种抗β-淀粉样蛋白单克隆抗体，将是第一个从 III 期临床试验中出现的此类药物。
本综述涵盖的领域
对 2009 年和 2010 年的 bapineuzumab 的主要文献进行了全面回顾，以及 2003 年至 2009 年第一代抗β-淀粉样蛋白疫苗 AN1792 的文献。根据 www.clinicaltrials.gov，还讨论了目前正在开发的其他阿尔茨海默病免疫疗法。
读者将获得
除了对 bapineuzumab 的 II 期试验结果进行批判性评估外，本综述还考虑了整个阿尔茨海默病免疫疗法领域，包括未来的挑战。
带回家的信息
Bapineuzumab似乎能够降低阿尔茨海默病患者大脑中的β-淀粉样肽负荷。然而，特别是在 APOE 4 携带者中，其减缓疾病进展的能力仍不确定，血管源性水肿 - 一种剂量限制和潜在严重的不良反应 - 可能限制其临床适用性。
Zotero 插件