职业与膝髋关节骨关节炎行关节置换的相关性：病例对照研究。
Association between occupation and knee and hip replacement due to osteoarthritis: a case-control study.
机构信息
Department of Orthopedics, University Hospital, Eyrarlandsvegi, Akureyri, IS-600, Iceland.
出版信息
Arthritis Res Ther. 2010;12(3):R102. doi: 10.1186/ar3033. Epub 2010 May 24.
INTRODUCTION
The objective of this study was to examine the association between occupation and osteoarthritis (OA) leading to total knee (TKR) or hip (THR) joint replacement.
METHODS
The following is the case-control study design. All patients still living in Iceland who had had a TKR or THR due to OA as of the end of 2002 were invited to participate. First degree relatives of participating patients served as controls. N=1,408 cases (832 women) and n=1,082 controls (592 women), 60 years or older and who had adequately answered a questionnaire were analyzed. Occupations were classified according to international standards. Inheritance of occupations was calculated by using the Icelandic Genealogy Database.
RESULTS
The age adjusted odds ratio (OR) for male farmers getting a TKR due to OA was 5.1 (95% confidence interval (CI) 2.1 to 12.4) and for a male farmer getting a THR due to OA the OR was 3.6 (95% CI 2.1 to 6.2). The OR for a fisherman getting a TKR was 3.3 (95% CI 1.3 to 8.4). No other occupations showed increased risk for men. For women there was no increased risk for any occupation. Farming and fishing were also the occupations that showed the greatest degree of inheritance.
CONCLUSIONS
These results support an association in males between occupations with heavy physical load and both TKR and THR for OA.
简介
本研究旨在探讨职业与膝关节（TKR）或髋关节（THR）关节置换术相关的骨关节炎（OA）之间的关系。
方法
这是一项病例对照研究设计。所有仍居住在冰岛且截至 2002 年底因 OA 接受 TKR 或 THR 的患者均被邀请参与。患者的一级亲属作为对照。共纳入 n=1408 例病例（832 名女性）和 n=1082 名对照（592 名女性），年龄均在 60 岁及以上，且充分回答了问卷。职业按照国际标准进行分类。利用冰岛族谱数据库计算职业遗传情况。
结果
校正年龄后，男性农民因 OA 接受 TKR 的比值比（OR）为 5.1（95%置信区间（CI）2.1 至 12.4），男性农民因 OA 接受 THR 的 OR 为 3.6（95% CI 2.1 至 6.2）。男性渔民因 OA 接受 TKR 的 OR 为 3.3（95% CI 1.3 至 8.4）。没有其他职业显示男性患病风险增加。对于女性，任何职业均未显示出增加的患病风险。农业和渔业也是显示出最大遗传程度的职业。
结论
这些结果支持男性中体力负荷较大的职业与 TKR 和 THR 相关的 OA 之间存在关联。
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