D'Souza Jennifer C, Werner Robert A, Keyserling W Monroe, Gillespie Brenda, Rabourn Randall, Ulin Sheryl, Franzblau Alfred
Department of Environmental Health Sciences, The University of Michigan School of Public Health, Ann Arbor, Michigan, USA.
Am J Ind Med. 2008 Jan;51(1):37-46. doi: 10.1002/ajim.20512.
Few epidemiologic studies have addressed the exposure-response relationships between work activities and symptomatic knee osteoarthritis (OA). This analysis used data from a national survey and ergonomists' ratings to address this issue.
Interview and knee X-ray data were obtained from the Third National Health and Nutrition Examination Survey. Occupational ratings were obtained using ergonomists. A weighted logistic regression was used.
Among men, a significant exposure-response relationship was found between symptomatic knee OA and kneeling. In both genders, there was a significant trend in heavy lifting and severe symptomatic knee OA. Approximately 20.7% of knee OA can be attributed to kneeling >14% of the workday among men.
The significant exposure-response relationships suggest that modest reductions in certain occupational activities can reduce the burden of knee OA. The study was limited by unvalidated expert ratings. Research is needed to identify hazardous characteristics of work activities and to clarify exposure-response relationships.
很少有流行病学研究探讨工作活动与有症状的膝关节骨关节炎（OA）之间的暴露-反应关系。本分析使用了一项全国性调查的数据和人体工程学专家的评级来解决这一问题。
从第三次全国健康与营养检查调查中获取访谈和膝关节X线数据。使用人体工程学专家进行职业评级。采用加权逻辑回归分析。
在男性中，有症状的膝关节OA与跪地之间存在显著的暴露-反应关系。在男女两性中，重物搬运与严重有症状的膝关节OA之间存在显著趋势。男性中约20.7%的膝关节OA可归因于工作日跪地时间>14%。
显著的暴露-反应关系表明，适度减少某些职业活动可减轻膝关节OA的负担。本研究受到未经验证的专家评级的限制。需要开展研究以确定工作活动的危险特征并阐明暴露-反应关系。
