Rush Alzheimer's Disease Center, 600 South Paulina Street, Room 1038, Chicago, IL 60612, USA, Department of Medicine, Rush University Medical Center, Chicago, IL, USA.
Alzheimers Res Ther. 2010 May 13;2(3):9. doi: 10.1186/alzrt32.
The oldest old are the fastest growing segment of the US population but accurate estimates of the incidence of dementia in this age group have been elusive. Corrada and colleagues present data on the 5-year age-specific rates of dementia incidence in persons 90 years and older from The 90+ Study. Their findings show a continued exponential increase in dementia incidence after age 90 that mirrors the increase observed in persons aged 65 to 90, with a doubling every 5.5 years. This contrasts with previous smaller studies reporting a slowing of the increase in incidence after age 90. If confirmed, the continued increase, rather than a plateau, in the incidence of dementia in the oldest old has implications for proper healthcare planning. Strategies for prevention and treatment will require more information regarding risk factors and the etiopathogenesis of dementia in the oldest old.
最年长的老年人是美国人口增长最快的群体，但准确估计这一年龄组的痴呆症发病率一直难以捉摸。Corrada 及其同事在 90 岁及以上人群中呈现了 90+研究中关于 5 年特定年龄组痴呆症发病率的数据。他们的研究结果表明，在 90 岁以上人群中，痴呆症发病率呈持续指数增长，与 65 至 90 岁人群中观察到的增长情况相吻合，每 5.5 年翻一番。这与以前报告称 90 岁以后发病率增长放缓的较小研究形成了对比。如果得到证实，那么在最年长的老年人中，痴呆症发病率的持续增长而不是稳定，对适当的医疗保健规划具有重要意义。预防和治疗策略将需要更多关于最年长的老年人中痴呆症的风险因素和病因发病机制的信息。
