Department of Surgery, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University and University Hospital Maastricht, 6202 AZ Maastricht, the Netherlands.
Crit Care. 2010;14(3):152. doi: 10.1186/cc8971. Epub 2010 May 14.
Berg and colleagues report on amino acid exchange across the human brain during endotoxin infusion. Lipopolysaccharide infusion induced a decrease in the ratio between branched chain amino acids and aromatic amino acids, increased unidirectional phenylalanine uptake, and increased net brain glutamine release. Cerebral proteolysis is suggested to play a role, but the question is whether this is the case and why this would happen.
伯格及其同事报告了内毒素输注期间人类大脑中氨基酸的交换情况。脂多糖输注导致支链氨基酸与芳香族氨基酸的比例降低,苯丙氨酸单向摄取增加,脑内谷氨酰胺净释放增加。推测脑蛋白水解可能起作用,但问题是这种情况是否存在,以及为什么会发生这种情况。