从核盘菌IFO 9395中获得的经腹腔注射的β-1,3-葡聚糖（SSG）对小鼠肺泡巨噬细胞功能的影响。

Effect of intraperitoneally administered beta-1,3-glucan, SSG, obtained from Sclerotinia sclerotiorum IFO 9395 on the functions of murine alveolar macrophages.

作者信息

Sakurai T, Suzuki I, Kinoshita A, Oikawa S, Masuda A, Ohsawa M, Yadomae T

机构信息

Tokyo College of Pharmacy, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1991 Jan;39(1):214-7. doi: 10.1248/cpb.39.214.

DOI:10.1248/cpb.39.214

PMID:2049804

Abstract

The effect of intraperitoneally (i.p.) administered SSG, a beta-1,3-glucan obtained from the culture filtrate of the fungus Sclerotinia sclerotiorum IFO 9395, on the functions of alveolar macrophages (AM) in CDF1 mice was examined. SSG administered i.p. increased the number of AM and enhanced several functions of murine AM (lysosomal enzyme activity, phagocytic activity, candidacidal activity, H2O2 production and interleukin 1 (IL-1) production) at a dose of 250 micrograms/mouse on days 1 and 8, especially on day 8. Furthermore, SSG (250 micrograms/mouse) administered i.p. for 10 consecutive days significantly inhibited the experimental pulmonary metastasis of Lewis Lung Carcinoma (3LL) on BDF1 mice.

摘要

研究了腹腔注射（i.p.）来源于核盘菌IFO 9395培养滤液的β-1,3-葡聚糖SSG对CDF1小鼠肺泡巨噬细胞（AM）功能的影响。腹腔注射SSG可增加AM数量，并在第1天和第8天以250微克/小鼠的剂量增强小鼠AM的多种功能（溶酶体酶活性、吞噬活性、杀念珠菌活性、H2O2产生和白细胞介素1（IL-1）产生），尤其是在第8天。此外，连续10天腹腔注射SSG（250微克/小鼠）可显著抑制BDF1小鼠Lewis肺癌（3LL）的实验性肺转移。