Male-specific metabolism of simvastatin by rat liver microsomes.
作者信息
Uchiyama N, Kagami Y, Saitoh Y, Ohtawa M
机构信息
Central Research Laboratories, Banyu Pharmaceutical Co., Ltd., Tokyo, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1991 Jan;39(1):236-8. doi: 10.1248/cpb.39.236.
PMID:2049809
Abstract
Simvastatin was more effectively metabolized by the liver microsomes of male rats than females. The sex difference appeared in the composition of the metabolites. Two male-specific metabolites were identified by NMR and mass spectrometry as 3''-hydroxy and 3',3''-dihydroxy-delta 4',5' derivatives of simvastatin.
摘要
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