大鼠肝微粒体对辛伐他汀的雄性特异性代谢
Male-specific metabolism of simvastatin by rat liver microsomes.
作者信息
Uchiyama N, Kagami Y, Saitoh Y, Ohtawa M
机构信息
Central Research Laboratories, Banyu Pharmaceutical Co., Ltd., Tokyo, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1991 Jan;39(1):236-8. doi: 10.1248/cpb.39.236.
PMID:2049809
Abstract
Simvastatin was more effectively metabolized by the liver microsomes of male rats than females. The sex difference appeared in the composition of the metabolites. Two male-specific metabolites were identified by NMR and mass spectrometry as 3''-hydroxy and 3',3''-dihydroxy-delta 4',5' derivatives of simvastatin.
摘要
辛伐他汀在雄性大鼠肝脏微粒体中的代谢比雌性更有效。这种性别差异体现在代谢物的组成上。通过核磁共振和质谱鉴定出两种雄性特有的代谢物为辛伐他汀的3''-羟基和3',3''-二羟基-δ4',5'衍生物。
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