QT间期延长：婴儿猝死综合征的一个标志物？

Prolonged QT interval: a marker of sudden infant death syndrome?

作者信息

Perticone F, Ceravolo R, Mattioli P L

机构信息

Department of Medicina Sperimentale e Clinica, Medical School at Catanzaro, University of Reggio Calabria, Italy.

出版信息

Clin Cardiol. 1991 May;14(5):417-21. doi: 10.1002/clc.4960140510.

DOI:10.1002/clc.4960140510

PMID:2049892

Abstract

A prospective electrocardiographic study was performed in 1830 newborns to evaluate the predictive value of QT interval for sudden infant death syndrome (SIDS). Standard ECG, with babies asleep, was recorded at the ages of 4 days, 2, 4, 6 months, and 1 year. The QTc (+/- SD) was 392 +/- 22 at 4 days, 410 +/- 16 (p less than 0.0001) at 2 months (n = 1256), 404 +/- 16 at 4 months (n = 1015), 400 +/- 16 at 6 months (n = 895), and 398 +/- 15 at 1 year (n = 890). QTc values longer than the mean plus 3 standard deviations were considered prolonged. Heart rate values (beats/min) were 138 +/- 19 at 4 days, 141 +/- 13 at 2 months, 134 +/- 13 at 4 months, 133 +/- 13 at 6 months, and 128 +/- 14 at 1 year. In 34 babies the QT interval was prolonged (mean + 3SD) and 3 of these died suddenly: the first, at 3 months (QTc = 470 and HR = 147 at 4 days); the second after 7 weeks (QTc = 514, HR = 115); the third at 3 months (QTc = 464 and HR = 140 at 4 days).

摘要

对1830名新生儿进行了一项前瞻性心电图研究，以评估QT间期对婴儿猝死综合征（SIDS）的预测价值。在婴儿4天、2个月、4个月、6个月和1岁时记录标准心电图，记录时婴儿处于睡眠状态。4天时QTc（±标准差）为392±22，2个月时为410±16（p<0.0001，n=1256），4个月时为404±16（n=1015），6个月时为400±16（n=895），1岁时为398±15（n=890）。QTc值超过平均值加3个标准差被认为是延长的。心率值（次/分钟）4天时为138±19，2个月时为141±13，4个月时为134±13，6个月时为133±13，1岁时为128±14。34名婴儿的QT间期延长（平均值+3SD），其中3名突然死亡：第一名在3个月时（4天时QTc=470，HR=147）；第二名在7周后（QTc=514，HR=115）；第三名在3个月时（4天时QTc=464，HR=140）。