Long S, Nergårdh A
Scand J Urol Nephrol. 1978;12(1):23-6.
The autonomic receptor functions of ureteral smooth muscle were studied in vitro on strips of human ureter obtained at surgery. A dose-dependent, reproducible, contraction response to 5-hydroxytryptamine (Serotonin, 5-HT) was demonstrated. This response could be blocked by methysergide. Responses to acetylcholine and to drugs stimulating adrenergic receptor functions were also found, but they were weak and inconsistent. This suggests that contraction of ureteral smooth muscle is mediated through receptors which are sensitive to 5-hydroxytryptamine.
在体外对手术中获取的人输尿管条进行研究，以探讨输尿管平滑肌的自主受体功能。结果表明，输尿管平滑肌对5-羟色胺（血清素，5-HT）呈现剂量依赖性、可重复的收缩反应。这种反应可被甲基麦角新碱阻断。同时也发现了输尿管平滑肌对乙酰胆碱以及刺激肾上腺素能受体功能的药物有反应，但这些反应较弱且不一致。这表明输尿管平滑肌的收缩是通过对5-羟色胺敏感的受体介导的。
