人体中优先利用高密度脂蛋白中的游离胆固醇进行胆汁胆固醇分泌。
Preferential utilization of free cholesterol from high-density lipoproteins for biliary cholesterol secretion in man.
作者信息
Schwartz C C, Halloran L G, Vlahcevic Z R, Gregory D H, Swell L
出版信息
Science. 1978 Apr 7;200(4337):62-4. doi: 10.1126/science.204996.
PMID:204996
Abstract
High- and low-density lipoproteins carrying free cholesterol labeled with 3H or 14C were administered to a patient with a bile fistula. The free cholesterol from high-density lipoproteins was more rapidly incorporated into biliary cholesterol than the free cholesterol from low-density lipoproteins. These findings show that the liver in man selectively utilizes and secretes the free cholesterol from a particular lipoprotein.
摘要
将携带用³H或¹⁴C标记的游离胆固醇的高密度和低密度脂蛋白给予一名患有胆瘘的患者。与低密度脂蛋白中的游离胆固醇相比，高密度脂蛋白中的游离胆固醇更快地被整合到胆汁胆固醇中。这些发现表明，人类肝脏选择性地利用和分泌来自特定脂蛋白的游离胆固醇。
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