Knipper M, Breer H
Dept. Zoophysiology, University of Osnabrück, 4500 Osnabrück, F.R.G.
Neurochem Int. 1987;10(3):323-8. doi: 10.1016/0197-0186(87)90106-9.
Specific high affinity binding sites for phorbol esters have been demonstrated in the nervous tissue of locust. The binding was reduced by the kinase C-inhibitor polymyxin B. Phorbol esters in micromolar concentrations activated protein kinase C in subcellular preparations from locust ganglia. The same concentrations of phorbol esters significantly enhanced the high affinity transport of choline and the release of acetylcholine by locust synaptosomes.
在蝗虫的神经组织中已证实存在佛波酯的特异性高亲和力结合位点。这种结合可被蛋白激酶C抑制剂多粘菌素B降低。微摩尔浓度的佛波酯可激活蝗虫神经节亚细胞制剂中的蛋白激酶C。相同浓度的佛波酯能显著增强蝗虫突触体对胆碱的高亲和力转运及乙酰胆碱的释放。
