Iaffaioli R V, Frasci G, Facchini G, Pagliarulo C, Pacelli R, Scala S, Espinosa A, Bianco A R
Cattedra di Oncologia Medica, Università di Cagliari.
Eur J Gynaecol Oncol. 1991;12(1):69-75.
Thirty-nine patients with epithelial ovarian cancer admitted to the Division of Medical Oncology of the Medical School II of Naples were given 159 courses of alpha 2b interferon (30 Mil./sqm IU) intraperitoneally from October 1986 to November 1989. IFN was generally administered every three weeks, but six patients received the drug weekly at the same dose, for an additional period. In 15 patients IFN was added to standard systemic chemotherapy as first line treatment; the remaining patients, all pretreated (22 with minimal and 2 with no residual disease), received an intraperitoneal multidrug treatment combining IFN, cisplatin and mitoxantrone. Peritoneal access was achieved through a temporarily implanted 18 gauge catheter and the drug was instilled in a large fluid volume (2,000 ml) to ensure wide spread and uniform distribution. IFN was well tolerated: only one patient had to discontinue treatment because of severe fatigue. No major complication related to catheter implantation or function occurred. 3/15 untreated and 11/20 pretreated patients, evaluable for response, achieved a pathological complete response (pCR). In view of IFN's lack of significant toxicity and the safety and tolerability of a temporary small gauge catheter for peritoneal access, intraperitoneal chemotherapy including IFN should be useful in ovarian cancer patients with minimal or absent disease after first-line systemic treatment.
1986年10月至1989年11月期间，那不勒斯第二医学院医学肿瘤学部门收治的39例上皮性卵巢癌患者接受了159个疗程的α2b干扰素（3000万国际单位/平方米）腹腔内注射治疗。干扰素一般每三周给药一次，但有6例患者在额外一段时间内每周接受相同剂量的药物治疗。15例患者将干扰素作为一线治疗添加到标准全身化疗中；其余患者均接受过预处理（22例为微小残留病，2例无残留病），接受了一种将干扰素、顺铂和米托蒽醌联合的腹腔内多药治疗。通过临时植入的18号导管实现腹腔通路，药物注入大量液体（2000毫升）中以确保广泛且均匀的分布。干扰素耐受性良好：只有1例患者因严重疲劳不得不停止治疗。未发生与导管植入或功能相关的重大并发症。15例未接受过治疗和20例接受过预处理且可评估反应的患者中，3例和11例达到了病理完全缓解（pCR）。鉴于干扰素缺乏显著毒性以及临时小口径导管用于腹腔通路的安全性和耐受性，包括干扰素的腹腔内化疗对于一线全身治疗后微小残留病或无残留病的卵巢癌患者应是有用的。
