Matias A, Albino-Teixeira A, Polónia J, Azevedo I
Department of Pharmacology and Therapeutics, Faculty of Medicine, Porto, Portugal.
Eur J Pharmacol. 1991 Jan 25;193(1):101-4. doi: 10.1016/0014-2999(91)90206-6.
Adenosine has been shown recently to be the main factor responsible for the trophic effects of sympathetic innervation. As sympathetic denervation causes hypertrophic and hyperplastic changes reminiscent of those occurring in blood vessels of spontaneously hypertensive rats, we decided to study the effect of a continuous blockade of adenosine receptors on both blood vessel structure and blood pressure. A continuous infusion of 1,3-dipropyl-8-sulfophenylxanthine (DPSPX; 30 micrograms/kg per h for 7 days) to Wistar rats caused hyperplastic changes in peritoneal fibroblasts and mesenteric arterioles, hypertrophic changes in the smooth muscle of the tail artery and significant increase in the size of left ventricle myocardial cell nuclei. Both diastolic and systolic blood pressure increased significantly above control values. The results confirmed the trophic effects of adenosine and showed that chronic blockade of adenosine receptors causes arterial hypertension.
最近研究表明，腺苷是交感神经支配产生营养作用的主要因素。由于交感神经去支配会引起肥大和增生性变化，这与自发性高血压大鼠血管中发生的变化相似，因此我们决定研究持续阻断腺苷受体对血管结构和血压的影响。对Wistar大鼠持续输注1,3 - 二丙基 - 8 - 磺苯基黄嘌呤（DPSPX；每小时30微克/千克，持续7天），导致腹膜成纤维细胞和肠系膜小动脉发生增生性变化，尾动脉平滑肌发生肥大性变化，左心室心肌细胞核大小显著增加。舒张压和收缩压均显著高于对照值。结果证实了腺苷的营养作用，并表明慢性阻断腺苷受体会导致动脉高血压。
