School of Physiotherapy and Curtin Health Innovation Research Institute, Curtin University of Technology,, Perth, W.A., Australia.
Respiration. 2011;81(4):302-10. doi: 10.1159/000315142. Epub 2010 May 22.
Some individuals with moderate/severe persistent asthma develop irreversible airway obstruction. These individuals present with dyspnoea, exercise intolerance and impaired quality of life (QOL), all of which could potentially be alleviated with exercise training.
To investigate whether exercise training improves functional exercise capacity and QOL in middle-aged and older adults with fixed airway obstruction asthma (FAOA).
35 subjects aged 67.8 ± 10.6 years, with FEV(1) 59 ± 16% of predicted, were randomised to a 6-week 'intervention' period of supervised exercise training (n = 20) or usual care (n = 15). This period was preceded by a 3-week run-in period during which asthma control was assessed weekly. Functional exercise capacity (6-min walk distance, 6MWD) and QOL (Asthma QOL Questionnaire, AQLQ) were measured before, immediately following and 3 months after the intervention period.
34 subjects (exercise group, n = 19, and control group, n = 15) completed the intervention period. Relative to the control group, the exercise group had greater improvements immediately following and 3 months after the intervention in the AQLQ symptom domain (0.61, p = 0.001, and 0.57 points per item, p = 0.005) and AQLQ activity limitation domain (0.43, p = 0.04, and 0.55 points per item, p = 0.04). 6MWD increased (36 ± 37 m, p < 0.01) in the exercise group immediately following training and remained elevated (34 ± 45 m, p < 0.01) at the 3-month follow-up. The magnitude of change in 6MWD between groups was not significant, despite no change in the control group.
Supervised exercise training improves symptoms and QOL in adults with FAOA.
一些患有中重度持续性哮喘的患者会出现不可逆的气道阻塞。这些患者会出现呼吸困难、运动不耐受和生活质量受损（QOL），所有这些都可以通过运动训练得到缓解。
研究运动训练是否能改善中年和老年固定气道阻塞性哮喘（FAOA）患者的功能运动能力和生活质量。
35 名年龄为 67.8 ± 10.6 岁的受试者，FEV(1)占预计值的 59 ± 16%，随机分为 6 周的监督运动训练（n = 20）或常规护理（n = 15）干预组。在此之前，进行了为期 3 周的适应期，每周评估哮喘控制情况。在干预期之前、之后立即和之后 3 个月测量功能运动能力（6 分钟步行距离，6MWD）和生活质量（哮喘生活质量问卷，AQLQ）。
34 名受试者（运动组，n = 19，对照组，n = 15）完成了干预期。与对照组相比，运动组在干预后立即和 3 个月后 AQLQ 症状域（0.61，p = 0.001，每项 0.57 分）和 AQLQ 活动受限域（0.43，p = 0.04，每项 0.55 分）有更大的改善。6MWD 在运动组中立即增加（36 ± 37 m，p < 0.01），并在 3 个月随访时仍保持升高（34 ± 45 m，p < 0.01）。尽管对照组没有变化，但两组之间 6MWD 的变化幅度没有显著差异。
监督运动训练可改善 FAOA 成人的症状和生活质量。
