Department of Pediatrics, Jordan University of Science and Technology, Irbid, Jordan.
Acta Haematol. 2010;124(1):1-4. doi: 10.1159/000314680. Epub 2010 May 21.
Neonatal extremity gangrene is rare, even rarer are those born with evidence of intrauterine vascular occlusion. Intrauterine limb ischemia has been attributed to several etiological factors which include thromboembolic disease occluding the arteries of the affected limb or compression of the limb during intrauterine life. In this report, we present a case of brachioradial arterial thrombosis associated with mild homocysteinemia and double heterozygosity of methylenetetrahydrofolate reductase 677C-T and factor V Leiden gene mutations. We suggest investigating the neonates and their mothers for possible genetic prothrombotic risk factors when they present with intrauterine thrombosis as this issue is important for management and counseling.
新生儿肢端坏疽罕见，更罕见的是那些出生时就有宫内血管阻塞证据的病例。宫内肢体缺血归因于多种病因，包括血栓栓塞性疾病阻塞受累肢体的动脉，或宫内生命期间肢体受压。在本报告中，我们介绍了一例与轻度高同型半胱氨酸血症和亚甲基四氢叶酸还原酶 677C-T 及因子 V 莱顿基因突变双重杂合相关的肱桡动脉血栓形成病例。我们建议，当新生儿及其母亲出现宫内血栓形成时，应调查可能的遗传性血栓形成危险因素，因为这对管理和咨询很重要。
